| Mendelian disorders | Chromosomal disorders |
|---|---|
| $(1)$ These are caused by an alteration or mutation in a single gene. | $(1)$ These are caused by the absence,excess,or abnormal arrangement of one or more chromosomes. |
| $(2)$ They are transmitted to subsequent generations following Mendelian principles of inheritance. | $(2)$ They are generally not transmitted as the affected individuals are often sterile. |
| $(3)$ They can be recessive or dominant in nature. | $(3)$ These are typically associated with large-scale genomic changes and are often dominant in their phenotypic expression. |
| $(4)$ Examples: Colour blindness,Phenylketonuria,Haemophilia. | $(4)$ Examples: Down's syndrome,Turner's syndrome,Klinefelter's syndrome. |
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